Thermogenetics is described as an approach for controlling nerve cell electrical activity using delivered exogenous, genetically encoded molecules responsive to external stimuli.
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thermogenetics
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With the development of optogenetics and thermogenetics, the molecular tools for cellular control are continuously being optimized, studied, and modified, expanding both their applications and their biomedical uses.
These approaches include optogenetics (overviewed in Part I), as well as chemogenetics and thermogenetics (described here, in Part II)
In fly neuroscience, temperature-controlled perturbation of neural activity, sometimes called "thermogenetics," has been an invaluable tool that predates the advent of optogenetics.
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Optogenetic and thermogenetic activation methods are described as extending beyond neurobiology into cardiovascular research, potential cancer therapy, and metabolic control.
Optogenetic and thermogenetic activation methods are used beyond neurobiology, including in cardiovascular research, potential cancer therapy, and metabolic control.
The review considers applications of optogenetic and thermogenetic molecular tools for activation of non-neuronal tissues and mammalian cells.
Molecular tools for optogenetics and thermogenetics are being continuously optimized, studied, and modified, expanding their applications and biomedical uses.
The molecular tools for cellular control in optogenetics and thermogenetics are continuously being optimized, studied, and modified, with expanding applications and biomedical uses.
Minimally invasive methods for brain tissue stimulation are becoming a basic element in the neuroscience toolbox for direct investigation of complex neuronal systems.
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minimally invasive methods for brain tissue stimulation are becoming the basic element in the toolbox of those involved in the field
Optogenetics, chemogenetics, and thermogenetics are presented as complementary rather than competing techniques.
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The latter circumstance is an indication that these are rather complementary than competing techniques.
Thermogenetics was an invaluable neural perturbation tool in fly neuroscience before optogenetics.
Targeted manipulation of electrically excitable cells aims to control electrical activity to either excite cells and generate action potentials or inhibit cells and suppress excitatory currents.
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In the case of electrically excitable cells, the aim of the manipulation is to control the cells' electrical activity, with the result being either excitation with subsequent generation of an action potential or inhibition and suppression of the excitatory currents.
This review describes genetically encoded approaches for targeted control of nerve cell electrical activity, focusing in Part II on chemogenetics and thermogenetics.
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In this review, we describe three approaches that are based on the delivery of exogenous, genetically encoded molecules sensitive to external stimuli into the nervous tissue. These approaches include optogenetics (overviewed in Part I), as well as chemogenetics and thermogenetics (described here, in Part II)