First-pass extracted concept

thrombus formation during sepsis

Candidate: concept label1 source documents4 linked claims
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Evidence Snippets

Recent research has also shed light on the critical role of thrombus formation, which prevents the dissemination of microorganisms.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1mechanistic summarysupports2017Source 1DOIPubMed

Histones, HMGB1, microparticles, and secreted granule proteins are described as important contributors to clot formation in sepsis.

Quoted textsource-backed
In addition to the cellular components, alarmins such as histones and high-mobility group box 1, microparticles and secreted granule proteins are all important for clot formation.
Claim 2mechanistic summarysupports2017Source 1DOIPubMed

Inflammatory responses and coagulation activation cooperate in a complex and synchronous manner during host defense against infection.

Quoted textsource-backed
The inflammatory response and the activation of coagulation are two important responses in a host's defense against infection. These mechanisms do not work independently, but cooperate in a complex and synchronous manner.
Claim 3mechanistic summarysupports2017Source 1DOIPubMed

Leukocytes, platelets, erythrocytes, and vascular endothelial cells are described as significant cellular contributors to thrombus development together with coagulation activation in sepsis.

Quoted textsource-backed
The cellular components of blood vessels, i.e. leukocytes, platelets, erythrocytes, and vascular endothelial cells, play significant roles in the development of thrombi in combination with activation of the coagulation system.
Claim 4mechanistic summarysupports2017Source 1DOIPubMed

Thrombus formation is described as playing a critical role in preventing dissemination of microorganisms during sepsis.

Quoted textsource-backed
Recent research has also shed light on the critical role of thrombus formation, which prevents the dissemination of microorganisms.