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First-pass extracted concept

TIE2/Tek pathway

Candidate: concept label1 source documents4 linked claims
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Aliases

TEK, Tie2

Evidence Snippets

Modulation of the Receptor Tyrosine Kinase TIE2/Tek Pathway by NRF2 Activation in Neurovascular Endothelial Cells.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1expression regulationsupports2026Source 1DOIPubMed

NRF2 activation downregulates TIE2/Tek expression in mouse neuroendothelial cells.

Quoted textsource-backed
Among these, the TIE2/Tek receptor, essential for vascular development and integrity, was downregulated upon NRF2 activation
Claim 2mechanism independencesupports2026Source 1DOIPubMed

TIE2/Tek repression after NRF2 activation is independent of the NRF2 repressor BACH1.

Quoted textsource-backed
Hemin treatment and knockdown revealed that TIE2/Tek repression is independent of the NRF2 repressor BACH1.
Claim 3mechanistic exclusionsupports2026Source 1DOIPubMed

Available mRNA stability and ChIP analyses do not support post-transcriptional or direct transcriptional repression of TIE2/Tek by NRF2.

Quoted textsource-backed
mRNA stability and ChIP analyses indicated no post-transcriptional or direct transcriptional repression by NRF2.
Claim 4mechanistic inferencesupports2026Source 1DOIPubMed

The findings suggest an alternative NRF2-dependent mechanism affects TIE2/Tek levels and may influence angiogenic regulation.

Quoted textsource-backed
These findings suggest an alternative NRF2-dependent mechanism affecting TIE2/Tek levels and potentially influencing angiogenic regulation.