First-pass extracted concept

Tissue morphogenesis

Candidate: concept label1 source documents4 linked claims

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Evidence Snippets

Tissue morphogenesis often generates mechanical forces that alter cell shapes and arrangements, resembling collective cell migration-like behaviors.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2024Seminars in Cell and Developmental BiologyDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1application scope summarysupports2024Source 1DOI PubMed

The review describes in vivo applications of optogenetic methods to dissect collective cell migration and tissue morphogenesis during development and highlights promising future approaches.

Claim 2method capability summarysupports2024Source 1DOI PubMed

Optogenetics enables spatiotemporal control of protein activity at subcellular, cellular, and tissue levels and is presented as a strong strategy for studying developmental collective migration and morphogenesis.

Claim 3method limitation summarysupports2024Source 1DOI PubMed

Traditional genetic approaches often face challenges and limitations in dissecting collective cell migration and tissue morphogenesis in complex developmental tissues.

Claim 4review scope summarysupports2024Source 1DOI PubMed

Collective cell migration during development is often coupled to other cellular and tissue processes and influenced by surrounding environments, making mechanistic dissection difficult.