Mounting evidence from large-scale association studies has identified transmembrane BAX inhibitor motif-containing 1 (TMBIM1) as a promising candidate gene in colorectal cancer (CRC) pathogenesis.
First-pass extracted concept
TMBIM1
Candidate: concept label1 source documents5 linked claims
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Aliases
transmembrane BAX inhibitor motif-containing 1
Evidence Snippets
Supporting Sources
Linked Claims
TMBIM1 deficiency suppresses growth in normal colonic epithelial NCM460 cells.
Quoted textsource-backed
In normal colonic epithelial cells (NCM460), TMBIM1 deficiency triggered distinct morphological changes and suppressed cellular growth.
TMBIM1 knockdown enhances proliferation and pro-tumorigenic characteristics in malignant HCT-116 cells.
Quoted textsource-backed
Conversely, in malignant HCT-116 cells, TMBIM1 knockdown paradoxically enhanced proliferation and other pro-tumorigenic characteristics, suggesting context-dependent functions.
TMBIM1 expression is reduced in human colon cancer tissues.
Quoted textsource-backed
Our clinical analysis confirmed this association, demonstrating significantly reduced TMBIM1 expression in human colon cancer tissues.
Loss of TMBIM1 in MSI-H cells promotes tumorigenesis via E-cadherin suppression and loss of epithelial integrity.
Quoted textsource-backed
We therefore define a context-dependent tumor-suppressive mechanism for TMBIM1, wherein its loss in MSI-H cells promotes tumorigenesis via E-cadherin suppression and the consequent loss of epithelial integrity.
TMBIM1 knockdown is associated with significant down-regulation of E-cadherin/CDH1.
Quoted textsource-backed
Mechanistic investigations further identified E-cadherin (CDH1) as a key downstream effector, showing significant down-regulation following TMBIM1 knockdown.