The abstract states that new transgenic fluorescent reporter and Cre-driver/reporter lines enabled discovery of additional striatal GABAergic interneuron subtypes. A TH-expressing interneuron class is specifically said to have been first revealed in a transgenic TH EGFP reporter mouse line.
First-pass extracted concept
transgenic fluorescent reporter and Cre-driver/reporter lines
Candidate: concept label1 source documents4 linked claims
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Aliases
Cre-driver/reporter lines, TH EGFP reporter mouse line, transgenic fluorescent reporter lines
Extracted Explainers
Evidence Snippets
With the application of new transgenic fluorescent reporter and Cre-driver/reporter lines... several additional subtypes of novel striatal GABAergic interneurons have been discovered... a recently discovered novel tyrosine hydroxylase (TH) expressing GABAergic interneuron class first revealed in transgenic TH EGFP reporter mouse line
Supporting Sources
Linked Claims
Striatal GABAergic interneurons participate in highly selective afferent inputs and synaptic connections among interneuron subtypes and spiny neurons that form functional networks and ensembles of spiny neurons.
A novel tyrosine hydroxylase-expressing GABAergic interneuron class was first revealed in a transgenic TH EGFP reporter mouse line.
New transgenic fluorescent reporter and Cre-driver/reporter lines together with optogenetic, chemogenetic, and viral transduction methods enabled discovery of additional subtypes of striatal GABAergic interneurons and the synaptic networks in which they are embedded.
The hypothesis that striatal GABAergic interneurons control spiny neuron firing principally by simple feedforward or feedback inhibition is incomplete.