First-pass extracted concept

transient receptor potential channels

Candidate: concept label2 source documents2 linked claims

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Aliases

TRP channels

Evidence Snippets

We further discuss the roles of key endogenous Ca2+ channels—including transient receptor potential (TRP) channels and store-operated Ca2+ entry (SOCE; STIM/Orai)—in orchestrating SC activation under physiological and injury-induced conditions.

Evidence 1Source 1DOIprovenance

In this review, we introduce the mechanosensitive channel of large conductance, transient receptor potential, channels of the two-pore-domain potassium family, Piezo and the recent progress on their application in sonogenetics.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025PPRDOI

1 evidence snippet 1 linked claim Claim 1

Source 2primary paper2019MEDDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Linked Claims

Claim 1mechanistic relationshipsupports2025Source 1DOI

TRP channels and store-operated Ca2+ entry via STIM/Orai are discussed as key endogenous Ca2+ pathways orchestrating Schwann-cell activation under physiological and injury-induced conditions.

Quoted textsource-backed

We further discuss the roles of key endogenous Ca2+ channels—including transient receptor potential (TRP) channels and store-operated Ca2+ entry (SOCE; STIM/Orai)—in orchestrating SC activation under physiological and injury-induced conditions.

Claim 2review scopesupports2019Source 2DOI PubMed

The review covers MscL, transient receptor potential channels, two-pore-domain potassium family channels, and Piezo channels in the context of sonogenetics.

Quoted textsource-backed

In this review, we introduce the mechanosensitive channel of large conductance, transient receptor potential, channels of the two-pore-domain potassium family, Piezo and the recent progress on their application in sonogenetics.