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TRIM21-mediated intracellular immunity

Candidate: concept label1 source documents6 linked claims
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Aliases

intracellular antibody-mediated immunity

Evidence Snippets

Tripartite motif containing-21 (TRIM21) is a cytosolic ubiquitin ligase and antibody receptor that provides a last line of defense against invading viruses.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1interaction summarysupports2019Source 1DOIPubMed

The review states that TRIM21 may synergize with the complement system to block viral replication and transgene expression.

Quoted textsource-backed
In addition, TRIM21 may synergize with the complement system to block viral replication as well as transgene expression.
Claim 2mechanism summarysupports2019Source 1DOIPubMed

TRIM21 functions as a cytosolic antibody receptor and ubiquitin ligase that intercepts antibody-coated viruses after cell entry.

Quoted textsource-backed
Tripartite motif containing-21 (TRIM21) is a cytosolic ubiquitin ligase and antibody receptor that provides a last line of defense against invading viruses. It does so by acting as a sensor that intercepts antibody-coated viruses that have evaded extracellular neutralization and breached the cell membrane.
Claim 3mechanism summarysupports2019Source 1DOIPubMed

Upon binding Fc on antibody-coated viruses, TRIM21 triggers both antiviral effector activity and signaling that prevent viral replication and induce an antiviral cellular state.

Quoted textsource-backed
Upon engagement of the Fc of antibodies bound to viruses, TRIM21 triggers a coordinated effector and signaling response that prevents viral replication while at the same time inducing an anti-viral cellular state.
Claim 4regulation summarysupports2019Source 1DOIPubMed

The dual effector and signaling functions of TRIM21 are regulated by auto-ubiquitination and phosphorylation.

Quoted textsource-backed
This dual effector function is tightly regulated by auto-ubiquitination and phosphorylation.
Claim 5therapeutic implicationsupports2019Source 1DOIPubMed

The review states that TRIM21 has been detrimental in adenovirus-based gene therapy.

Quoted textsource-backed
Therapeutically, TRIM21 has been shown to be detrimental in adenovirus based gene therapy
Claim 6therapeutic implicationsupports2019Source 1DOIPubMed

The review states that TRIM21 may be favorably utilized to prevent tau aggregation in neurodegenerative disorders.

Quoted textsource-backed
while it may be favorably utilized to prevent tau aggregation in neurodegenerative disorders.