Astrocytes, the most abundant glial cells in the brain, are wired into neural circuits through close contact with neuronal pre- and post-synapses, called tripartite synapses.
First-pass extracted concept
tripartite synapse
Candidate: concept label3 source documents5 linked claims
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Aliases
tripartite synapses
Evidence Snippets
The title explicitly frames the review as 'a tripartite view' on cortical circuit development involving astrocytes, neurons, and synapses.
High-signal enrichment leads cluster around the main mechanisms emphasized by the review: astrocyte-driven synaptogenesis, synapse elimination/pruning, tripartite-synapse structural/functional regulation, gliotransmission and D-serine-dependent plasticity, and neurotransmitter uptake/homeostasis.
Supporting Sources
Linked Claims
Mutual communication between neurons and astrocytes is crucial for neural circuit dynamics and animal behaviour.
This review synthesizes evidence about astrocytes, neurons, and synapses as a tripartite framework for cortical circuit development.
The review covers astrocyte roles in synapse formation as well as neurotransmitter uptake and recycling.
Quoted textsource-backed
It includes the emerging functions of astrocytes, such as a role in synapse formation, as well as more established roles, including the uptake and recycling of neurotransmitters.
Astrocytes regulate multiple aspects of neuronal and synaptic function from development through adulthood.
Quoted textsource-backed
Astrocytes regulate multiple aspects of neuronal and synaptic function from development through to adulthood.
Astrocyte-neuron interactions are diverse and continuously contribute to maintaining correct brain function.
Quoted textsource-backed
This broad approach covers the many ways astrocytes and neurons constantly interact to maintain the correct functioning of the brain.