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TRP-4

Candidate: concept label1 source documents4 linked claims
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Extracted Explainers

What the tool is doing

The abstract describes TRP-4 as the pore-forming subunit of a mechanosensitive channel required for ultrasound-evoked reversal behavior in C. elegans.

Source 1DOIPubMed

Resources required

The paper studies TRP-4 through mutant analysis and neuron-specific overexpression in C. elegans.

Source 1DOIPubMed

What problem it solves

TRP-4 is presented as part of the molecular machinery that helps convert ultrasound stimuli into behavioral responses.

Source 1DOIPubMed

What it does not solve

The abstract does not show that TRP-4 alone is sufficient for the full endogenous response pathway.

Source 1DOIPubMed

Alternatives

MEC-4 is presented as a second required mechanosensitive pathway component.

Source 1DOIPubMed

Evidence Snippets

the pore-forming subunit of the mechanosensitive channel TRP-4
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1genetic interactionsupports2022Source 1DOIPubMed

The trp-4;mec-4 double mutant shows a stronger ultrasound-evoked behavioral deficit than either single mutant.

Quoted textsource-backed
the trp-4;mec-4 double mutant shows a stronger behavioral deficit compared to either single mutant
Claim 2genetic requirementsupports2022Source 1DOIPubMed

TRP-4 and MEC-4 are both required for the ultrasound-evoked reversal response in C. elegans.

Quoted textsource-backed
TRP-4, and a DEG/ENaC/ASIC ion channel MEC-4, are both required for this ultrasound-evoked reversal response
Claim 3mechanistic requirementsupports2022Source 1DOIPubMed

At least two mechanosensitive proteins act together to generate ultrasound-evoked behavioral responses in C. elegans.

Quoted textsource-backed
we show that at least two mechanosensitive proteins act together to generate C. elegans behavioral responses to ultrasound stimuli
Claim 4rescuesupports2022Source 1DOIPubMed

Overexpressing TRP-4 in specific chemosensory neurons can rescue the ultrasound-triggered behavioral deficit in the mec-4 null mutant.

Quoted textsource-backed
overexpressing TRP-4 in specific chemosensory neurons can rescue the ultrasound-triggered behavioral deficit in the mec-4 null mutant