This label refers to macrophages in tumors that the abstract describes as having an alternative-like activation phenotype. The review frames them as functionally similar in some respects to M2-polarized macrophages.
First-pass extracted concept
tumor-associated macrophages
Candidate: concept label2 source documents6 linked claims
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Aliases
TAM, TAMs
Extracted Explainers
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Evidence Snippets
In human breast carcinomas, tumor-associated macrophage (TAM) density correlates with poor prognosis.
Similar functions are also exerted by tumor-associated macrophages (TAM), which also display an alternative-like activation phenotype and play a detrimental pro-tumoral role.
Supporting Sources
Linked Claims
In mouse models of breast cancer, eliminating macrophages from the tumor site retards tumor progression.
Recent developments support the existence of at least two distinct tumor-associated macrophage subpopulations in mammary tumors distinguished by markers such as CD206 or MHC II and by different in vivo behavior.
In human breast carcinomas, higher tumor-associated macrophage density correlates with poor prognosis.
Breast tumor-associated macrophages have often been propagated as anti-inflammatory M2-like cells.
Further refinement of the molecular and functional heterogeneity of breast tumor-associated macrophages could affect their usefulness as therapeutic targets.
Tumor-associated macrophages display an alternative-like activation phenotype and play a detrimental pro-tumoral role.
Quoted textsource-backed
tumor-associated macrophages (TAM), which also display an alternative-like activation phenotype and play a detrimental pro-tumoral role