TIME is the review's central framework for describing the local tumor environment that shapes antitumor immunity and therapy effectiveness.
First-pass extracted concept
tumor immune microenvironment
Candidate: concept label2 source documents6 linked claims
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Aliases
TIME
Extracted Explainers
What the tool is doing
What problem it solves
What it does not solve
Evidence Snippets
we begin with a foundational overview of the classification of CGT in treating solid tumors and explore how it targets the cross-talk between cancer cells and the tumor immune microenvironment from cellular and molecular perspectives.
The review title explicitly names the tumor immune microenvironment (TIME) as the central subject for effective therapy.
Supporting Sources
Linked Claims
Cell and gene therapy can target cross-talk between cancer cells and the tumor immune microenvironment from cellular and molecular perspectives.
Cell and gene therapy not only remodels the local tumor immune microenvironment but also has long-term effects on the systemic immune response.
The development of cell and gene therapy is proposed to shift cancer treatment from targeting tumor tissues alone toward restoring disrupted cancer-immune balance as a whole.
Adjacent literature linked in the supplied summary positions immune contexture, Immunoscore, and the cancer immunogram as related frameworks for interpreting or operationalizing TIME-relevant variation.
The supplied summary links colorectal consensus molecular subtypes to distinct immune and stromal states relevant to the tumor immune microenvironment.
The review frames the tumor immune microenvironment as a central determinant of effective cancer therapy.