Back to first-pass browser

First-pass extracted concept

tumour microenvironment modulation by HER2 in oesophagogastric adenocarcinoma

Candidate: concept label1 source documents5 linked claims
Jump to evidenceJump to sourcesJump to claims
Live refresh every 5sNext refresh in 5s

Evidence Snippets

HER2 significantly influences the tumour microenvironment (TME) through various mechanisms, creating a niche that supports tumour progression, immune evasion, and therapeutic resistance.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1immune modulationsupports2025Source 1DOIPubMed

HER2 modulates the tumour immune microenvironment by downregulating MHC molecules and recruiting immunosuppressive cells including regulatory T cells and tumour-associated macrophages.

Quoted textsource-backed
HER2 also modulates the tumour immune microenvironment (TIME) by downregulating MHC molecules and recruiting immunosuppressive cells, including regulatory T-cells (T-reg) and tumour-associated macrophages (TAMs)...
Claim 2mechanistic rolesupports2025Source 1DOIPubMed

In HER2-positive oesophagogastric adenocarcinoma, HER2 influences the tumour microenvironment in ways that support tumour progression, immune evasion, and therapeutic resistance.

Quoted textsource-backed
HER2 significantly influences the tumour microenvironment (TME) through various mechanisms, creating a niche that supports tumour progression, immune evasion, and therapeutic resistance.
Claim 3pathway associationsupports2025Source 1DOIPubMed

In HER2-positive oesophagogastric adenocarcinoma, aberrant PI3K/AKT and MAPK/ERK signalling enhance tumour cell survival and proliferation.

Quoted textsource-backed
In HER2-positive EGA, aberrant signalling pathways, such as PI3K/AKT and MAPK/ERK, enhance tumour cell survival and proliferation...
Claim 4pathway associationsupports2025Source 1DOIPubMed

In HER2-positive oesophagogastric adenocarcinoma, upregulation of VEGF fosters vascularization that supports tumour metabolic demands and proliferation.

Quoted textsource-backed
upregulation of angiogenic factors like VEGF fosters vascularization, meeting a tumour's metabolic demands and facilitating its proliferation.
Claim 5resistance associationsupports2025Source 1DOIPubMed

A pro-inflammatory, immunosuppressive microenvironment in HER2-positive oesophagogastric adenocarcinoma underpins resistance to HER2-targeted therapies.

Quoted textsource-backed
Together, these factors foster a pro-inflammatory, immunosuppressive microenvironment that underpins resistance to HER2-targeted therapies.