The ubiquitin proteasome system is presented as a biodegradation pathway that works alongside autophagy to maintain neuronal homeostasis.
First-pass extracted concept
Ubiquitin proteasome system
Candidate: concept label3 source documents7 linked claims
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Evidence Snippets
These signaling pathways include... the ubiquitin-proteasome system.
Autophagy and the ubiquitin-proteasome system are the two major quality control pathways responsible for cellular homeostasis.
A dynamic equilibrium between biosynthesis and biodegradation of sub-cellular components by ubiquitin proteasome system and autophagy is found to be responsible for sustaining the homeostasis of tyrosine hydroxylase-positive neurons.
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Linked Claims
The review summarizes that several natural compounds modify multiple inflammation-associated signaling pathways, including NF-κB, AP-1, PTKs, MAPKs, Nrf2, PI3K/AKT, and the ubiquitin-proteasome system.
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Through current study, an attempt is made to outline and highlight a wide variety of inflammation-associated signaling pathways that have been modified by several natural compounds. These signaling pathways include nuclear factor-kappa B (NF-κB), activator protein (AP)-1, protein tyrosine kinases (PTKs), mitogen-activated protein kinases (MAPKs), nuclear factor erythroid 2-related factor 2 (Nrf2) transcription factors, tyrosine phosphatidylinositol 3-kinase (PI3K)/AKT, and the ubiquitin-proteasome system.
Autophagy and the ubiquitin-proteasome system are the two major quality control pathways responsible for cellular homeostasis.
Autophagy and the ubiquitin-proteasome system intersect and communicate at multiple points to coordinate proteostasis and organelle homeostasis.
Autophagy and the ubiquitin-proteasome system protect against age-associated changes and many human diseases.
Ubiquitination serves as a degradation signal for both autophagy and the ubiquitin-proteasome system, but it is used differently by the two pathways.
Common principles and communication nodes linking autophagy and the ubiquitin-proteasome system may be therapeutically exploited.
Autophagy and the ubiquitin proteasome system jointly support homeostasis of tyrosine hydroxylase-positive neurons through biodegradation of sub-cellular components.