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ultrasound-evoked reversal behavior in Caenorhabditis elegans

Candidate: concept label1 source documents5 linked claims
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Aliases

ultrasound-evoked reversal response, ultrasound-triggered behavioral response

Extracted Explainers

What the tool is doing

The abstract uses reversal behavior as the measured organism-level response to ultrasound stimulation in C. elegans.

Source 1DOIPubMed

Resources required

The reported stimulus uses a 2.25 MHz ultrasound transducer and a single 10 msec pulse.

Source 1DOIPubMed

What problem it solves

This phenotype provides a behavioral readout for testing whether mechanosensitive proteins are required for ultrasound responses.

Source 1DOIPubMed

What it does not solve

The abstract does not provide finer mechanistic or cell-specific resolution for the full response pathway.

Source 1DOIPubMed

Evidence Snippets

these animals generate reversals in response to a single 10 msec pulse from a 2.25 MHz ultrasound transducer
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1behavioral responsesupports2022Source 1DOIPubMed

C. elegans generates reversal behavior in response to a single 10 msec pulse from a 2.25 MHz ultrasound transducer.

Quoted textsource-backed
these animals generate reversals in response to a single 10 msec pulse from a 2.25 MHz ultrasound transducer
Claim 2genetic interactionsupports2022Source 1DOIPubMed

The trp-4;mec-4 double mutant shows a stronger ultrasound-evoked behavioral deficit than either single mutant.

Quoted textsource-backed
the trp-4;mec-4 double mutant shows a stronger behavioral deficit compared to either single mutant
Claim 3genetic requirementsupports2022Source 1DOIPubMed

TRP-4 and MEC-4 are both required for the ultrasound-evoked reversal response in C. elegans.

Quoted textsource-backed
TRP-4, and a DEG/ENaC/ASIC ion channel MEC-4, are both required for this ultrasound-evoked reversal response
Claim 4mechanistic requirementsupports2022Source 1DOIPubMed

At least two mechanosensitive proteins act together to generate ultrasound-evoked behavioral responses in C. elegans.

Quoted textsource-backed
we show that at least two mechanosensitive proteins act together to generate C. elegans behavioral responses to ultrasound stimuli
Claim 5rescuesupports2022Source 1DOIPubMed

Overexpressing TRP-4 in specific chemosensory neurons can rescue the ultrasound-triggered behavioral deficit in the mec-4 null mutant.

Quoted textsource-backed
overexpressing TRP-4 in specific chemosensory neurons can rescue the ultrasound-triggered behavioral deficit in the mec-4 null mutant