First-pass extracted concept

ultrasound retinal stimulation

Candidate: concept label2 source documents5 linked claims

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Aliases

direct ultrasound stimulation on the retina, ultrasound stimulation of the retina

Extracted Explainers

What the tool is doing

Ultrasound retinal stimulation uses ultrasound to activate retinal neurons. The abstract states that it can work in both healthy and degenerated retinas and that high-frequency ultrasound can produce localized responses and patterned activity in visual circuits.

Source 2DOI PubMed

Resources required

It requires an ultrasound stimulation setup directed at the retina, particularly high-frequency ultrasound for localized and patterned responses. The abstract does not provide device architecture or assay details.

Source 2DOI PubMed

What problem it solves

It addresses the feasibility of noninvasive retinal neuromodulation and is discussed as a route toward a noninvasive retinal prosthesis.

Source 2DOI PubMed

What it does not solve

The abstract does not show that all engineering, safety, or prosthesis-development challenges are solved. It explicitly frames the field in terms of remaining opportunities and challenges.

Source 2DOI PubMed

Alternatives

The review compares ultrasound retinal stimulation with other neuromodulation technologies, but the abstract does not name those alternatives.

Source 2DOI PubMed

Evidence Snippets

Here, we show that direct ultrasound stimulation on the retina can evoke neuron activities from the visual centers including the superior colliculus and the primary visual cortex (V1), in either normal-sighted or retinal degenerated blind rats in vivo.

Evidence 1Source 1DOI PubMedprovenance

A significant amount of effort has been devoted to investigating the feasibility of noninvasive ultrasound retinal stimulation.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1primary paper2022MEDDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Source 2review2022MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1activity summarysupports2022Source 2DOI PubMed

Ultrasound can activate neurons in both healthy and degenerated retinas.

Claim 2feasibility summarysupports2022Source 2DOI PubMed

Noninvasive ultrasound retinal stimulation is a feasible emerging neuromodulation approach under active investigation.

Claim 3functional effectsupports2022Source 1DOI PubMed

Direct ultrasound stimulation of the retina evokes neural activity in the superior colliculus and primary visual cortex in vivo in normal-sighted and retinal degenerated blind rats.

Quoted textsource-backed

Here, we show that direct ultrasound stimulation on the retina can evoke neuron activities from the visual centers including the superior colliculus and the primary visual cortex (V1), in either normal-sighted or retinal degenerated blind rats in vivo.

Claim 4mechanism or property summarysupports2022Source 2DOI PubMed

High-frequency ultrasound can evoke localized neuronal responses and generate patterns in visual circuits during retinal stimulation.

Claim 5safety efficacysupports2022Source 1DOI PubMed

Ultrasound stimulation of the retina in vivo is described as a safe and effective approach with high spatiotemporal resolution and as a promising noninvasive visual prosthesis modality.

Quoted textsource-backed

Our findings demonstrate that ultrasound stimulation of the retina in vivo is a safe and effective approach with high spatiotemporal resolution, indicating a promising future of ultrasound stimulation as a novel and noninvasive visual prosthesis for translational applications in blind patients.