First-pass extracted concept

unified engram complex

Candidate: concept label1 source documents4 linked claims

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Evidence Snippets

engram of a specific memory are distributed among multiple brain regions that are functionally connected, referred to as a unified engram complex

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2022Nature CommunicationsDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1comparative performancesupports2022Source 1DOI PubMed

Simultaneous chemogenetic reactivation of multiple engram ensembles produced greater memory recall than reactivation of a single engram ensemble.

Quoted textsource-backed

Simultaneous chemogenetic reactivation of multiple engram ensembles conferred a greater level of memory recall than reactivation of a single engram ensemble

Claim 2functional connectivity resultsupports2022Source 1DOI PubMed

Optogenetic manipulation experiments revealed engram ensembles, many of which were functionally connected to hippocampal or amygdala engrams.

Quoted textsource-backed

Optogenetic manipulation experiments revealed engram ensembles, many of which were functionally connected to hippocampal or amygdala engrams.

Claim 3hypothesis supportsupports2022Source 1DOI PubMed

This study supports the unified engram complex hypothesis for memory storage.

Quoted textsource-backed

Overall, our study supports the unified engram complex hypothesis for memory storage.

Claim 4mapping resultsupports2022Source 1DOI PubMed

A partial map of the contextual fear conditioning memory engram complex was generated by characterizing encoding-activated neuronal ensembles across 247 brain regions in mice.

Quoted textsource-backed

Here, we report a partial map of the engram complex for contextual fear conditioning memory by characterizing encoding activated neuronal ensembles in 247 regions using tissue phenotyping in mice.