It is achieved by the site-specific incorporation of unnatural amino acids (Uaas) that carry light sensitive moieties serving as "pigments" that react to light via photo-decaging, cross-linking, or isomerization.
First-pass extracted concept
unnatural amino acids
Candidate: concept label1 source documents4 linked claims
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Aliases
Uaas, Uaas carrying light sensitive moieties
Evidence Snippets
Supporting Sources
Linked Claims
Cas9 has been engineered to enable light activation of genomic editing by CRISPR.
Quoted textsource-backed
Very recently, Cas9 protein has been engineered to enable light activation of genomic editing by CRISPR.
Proteins including ion channels, GPCRs, transporters, and kinases have been rendered light responsive using genetic code expansion-enabled unnatural amino acid functionalities.
Quoted textsource-backed
Over the last two decades, various proteins including ion channels, GPCRs, transporters, and kinases have been successfully rendered light responsive owing to the functionalities of Uaas.
The light-sensitive unnatural amino acids used in genetic code expansion can react to light via photo-decaging, cross-linking, or isomerization.
Quoted textsource-backed
Uaas that carry light sensitive moieties serving as "pigments" that react to light via photo-decaging, cross-linking, or isomerization
Genetic code expansion can transform light-insensitive proteins into novel photoreceptor proteins by site-specific incorporation of unnatural amino acids with light-sensitive moieties.
Quoted textsource-backed
Genetic code expansion (GCE) technology has provided new tools to transform light insensitive proteins into novel photoreceptor proteins. It is achieved by the site-specific incorporation of unnatural amino acids (Uaas) that carry light sensitive moieties