First-pass extracted concept

UspA

Candidate: concept label1 source documents8 linked claims

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Aliases

ubiquitin-specific protease UspA

Evidence Snippets

We characterized the novel ubiquitin-specific protease UspA of the mold Aspergillus nidulans, which corresponds to CSN-associated human Usp15 and interacts with six CSN subunits.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2019BiomoleculesDOI PubMed

1 evidence snippet 8 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1developmental phenotypesupports2019Source 1DOI PubMed

UspA accelerates asexual conidiospore formation and sexual development in Aspergillus nidulans.

Claim 2functional effectsupports2019Source 1DOI PubMed

UspA reduces the amount of ubiquitinated proteins during fungal development.

Claim 3gene cluster regulationsupports2019Source 1DOI PubMed

UspA supports repression of derivative of benzaldehyde secondary metabolite gene clusters.

Claim 4gene regulationsupports2019Source 1DOI PubMed

An intact COP9 signalosome represses uspA gene expression.

Claim 5mechanistic modelsupports2019Source 1DOI PubMed

Interplay between COP9 signalosome deneddylase, UspA deubiquitinase, and SCF-Fbx23 ensures accurate VeA levels that support fungal development and appropriate secondary metabolism.

Claim 6physical interactionsupports2019Source 1DOI PubMed

UspA interacts with six COP9 signalosome subunits in Aspergillus nidulans.

Claim 7protein level regulationsupports2019Source 1DOI PubMed

UspA reduces VeA protein levels.

Claim 8subcellular localizationsupports2019Source 1DOI PubMed

UspA localizes near nuclei and recruits proteins related to nuclear transport and transcriptional processing, suggesting a role in nuclear entry control.