The vault cap is the structural subject resolved in this paper. The abstract describes its symmetry, repeating module organization, and charge distribution.
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vault cap
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Here, we present a 2.25-angstrom cryo-electron microscopy structure of the vault cap, revealing an unexpected 13-fold symmetric arrangement that contrasts with the 39-fold symmetry of the vault body, with each repeating module of the cap formed by an asymmetric homotrimer of adjacent subunits.
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Linked Claims
The charge properties of the vault cap have implications for binding partner recruitment and engineering of modified vault particles.
Each repeating module of the vault cap is formed by an asymmetric homotrimer of adjacent subunits.
The center of the vault cap contains two concentric beta barrels surrounded by an interwoven two-layer stack of alpha helices.
The vault cap has a 13-fold symmetric arrangement that contrasts with the 39-fold symmetry of the vault body.
The vault cap has a positively charged exterior and a negatively charged interior surface.