VEGF-A controls angiogenic sprouting in the early postnatal retina by guiding filopodial extension
First-pass extracted concept
VEGF-A
Candidate: concept label1 source documents5 linked claims
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Aliases
vascular endothelial growth factor, VEGF
Evidence Snippets
Supporting Sources
Linked Claims
Endothelial tip cells respond to VEGF-A by guided migration, whereas proliferative responses to VEGF-A occur in sprout stalks.
Quoted textsource-backed
The tip cells respond to VEGF-A only by guided migration; the proliferative response to VEGF-A occurs in the sprout stalks.
Tip cell migration depends on a VEGF-A gradient, whereas proliferation is regulated by VEGF-A concentration.
Quoted textsource-backed
Whereas tip cell migration depends on a gradient of VEGF-A, proliferation is regulated by its concentration.
VEGF-A controls angiogenic sprouting in the early postnatal retina by guiding filopodial extension from endothelial tip cells.
Quoted textsource-backed
We show here that VEGF-A controls angiogenic sprouting in the early postnatal retina by guiding filopodial extension from specialized endothelial cells situated at the tips of the vascular sprouts.
Vessel patterning during retinal angiogenesis depends on the balance between VEGF-A gradient and concentration properties that regulate distinct endothelial cell responses.
Quoted textsource-backed
Thus, vessel patterning during retinal angiogenesis depends on the balance between two different qualities of the extracellular VEGF-A distribution, which regulate distinct cellular responses in defined populations of endothelial cells.
VEGF-A-mediated tip cell migration and stalk proliferation are both mediated by agonistic activity on VEGF receptor 2.
Quoted textsource-backed
These two cellular responses are both mediated by agonistic activity of VEGF-A on VEGF receptor 2.