Pharmacological activation of hM3D(Gq) DREADDs in neurons projecting from the ventral tegmental area (VTA) to the nucleus accumbens (AcbSh) induced a sex-dependent shift in the allocation of behavior.
First-pass extracted concept
ventral tegmental area to nucleus accumbens shell circuit
Candidate: concept label1 source documents5 linked claims
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Aliases
VTA-AcbSh circuit, VTA to AcbSh
Evidence Snippets
Supporting Sources
Linked Claims
The VTA-AcbSh circuit is fundamentally involved in behavioral allocation.
Quoted textsource-backed
Collectively, the VTA-AcbSh circuit is fundamentally involved in behavioral allocation affording a key target for the development of novel pharmacotherapies.
Chemogenetic activation of hM3D(Gq) in VTA-to-AcbSh projecting neurons induced a sex-dependent shift in behavioral allocation in rodents.
Quoted textsource-backed
Pharmacological activation of hM3D(Gq) DREADDs in neurons projecting from the ventral tegmental area (VTA) to the nucleus accumbens (AcbSh) induced a sex-dependent shift in the allocation of behavior in rodents transduced with DREADDs.
In female DREADD-transduced rodents, pharmacological activation of the VTA-AcbSh circuit decreased cocaine-reinforced responding.
Quoted textsource-backed
female DREADDs rodents, in sharp contrast, displayed a prominent decrease in drug-reinforced (i.e., cocaine) responding
In male DREADD-transduced animals, pharmacological activation of the VTA-AcbSh circuit increased responding for sucrose reward.
Quoted textsource-backed
Specifically, male DREADDs animals exhibited a robust increase in responding for a natural (i.e., sucrose) reward following pharmacological activation of the VTA-AcbSh circuit
Sequential use of hM3D(Gq) and KORD in the same neuronal population validated a role for the VTA-AcbSh circuit in reinforced responding when natural and drug rewards were concurrently available.
Quoted textsource-backed
The sequential activation of hM3D(Gq) and KORD DREADDs within the same neuronal population validated the role of the VTA-AcbSh circuit in reinforced responding for concurrently available natural and drug rewards.