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ventromedial hypothalamic steroidogenic factor-1 neurons

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Aliases

SF1 neurons, ventromedial hypothalamic SF1 neurons

Evidence Snippets

Ventromedial hypothalamic steroidogenic factor-1 (SF1) neurons are activated following exercise, and repeated training results in increased post-exercise SF1 neuron activation.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1activity changesupports2026Source 1DOIPubMed

Ventromedial hypothalamic SF1 neurons are activated following exercise, and repeated training increases post-exercise SF1 neuron activation.

Quoted textsource-backed
Ventromedial hypothalamic steroidogenic factor-1 (SF1) neurons are activated following exercise, and repeated training results in increased post-exercise SF1 neuron activation.
Claim 2gain of function effectsupports2026Source 1DOIPubMed

Stimulation of SF1 neurons following exercise enhances gains in endurance.

Quoted textsource-backed
Conversely, stimulation of SF1 neurons following exercise enhances gains in endurance.
Claim 3loss of function effectsupports2026Source 1DOIPubMed

Inhibition of SF1 neuron output blocks endurance gains and metabolic improvements resulting from exercise training.

Quoted textsource-backed
Inhibition of SF1 neuron output blocks endurance gains and metabolic improvements that result from exercise training.
Claim 4mechanistic conclusionsupports2026Source 1DOIPubMed

Exercise-induced hypothalamic SF1 neuron activity is essential for coordinating physiological improvements following exercise training.

Quoted textsource-backed
These results demonstrate that exercise-induced hypothalamic SF1 neuron activity is essential for the coordination of physiological improvements following exercise training.
Claim 5necessitysupports2026Source 1DOIPubMed

Activation of the central nervous system following exercise is essential for subsequent endurance performance and metabolism benefits in mice.

Quoted textsource-backed
In mice, we find that activation of the central nervous system following exercise is essential for subsequent endurance performance and metabolism benefits.
Claim 6plasticity changesupports2026Source 1DOIPubMed

Exercise training increases intrinsic excitability and excitatory synapse density on SF1 neurons, consistent with hypothalamic plasticity encoding exercise history.

Quoted textsource-backed
Exercise training increases the intrinsic excitability and density of excitatory synapses on SF1 neurons, suggesting that exercise history is encoded through hypothalamic plasticity.