First-pass extracted concept

vHip→NAc-associated accumbal astrocytic ensemble

Candidate: concept label1 source documents5 linked claims

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Aliases

astrocytic ensemble, vHip→NAc ensemble

Evidence Snippets

Here, we identify a functionally distinct accumbal astrocytic ensemble, associated with the ventral hippocampus-NAc (vHip→NAc) circuit, that is critical for tetrahydrocannabinol (THC)-induced synaptic and behavioral impairments.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1intervention effectsupports2025Source 1DOI PubMed

Targeted attenuation of THC-induced calcium activity in the vHip→NAc-associated astrocytic ensemble prevents spatial learning and synaptic plasticity impairments.

Claim 2mechanistic rolesupports2025Source 1DOI PubMed

A functionally distinct accumbal astrocytic ensemble associated with the vHip→NAc circuit is critical for THC-induced synaptic and behavioral impairments.

Claim 3necessitysupports2025Source 1DOI PubMed

Astrocytic glutamate release within the vHip→NAc ensemble is required for THC-induced cognitive deficits.

Claim 4phenotypic effectsupports2025Source 1DOI PubMed

THC increases astrocytic calcium activity and glutamatergic tone within the nucleus accumbens.

Claim 5tool usesupports2025Source 1DOI PubMed

AstroLight was used to selectively manipulate the astrocytic ensemble associated with the vHip→NAc circuit.