Back to first-pass browser

First-pass extracted concept

vimentin

Candidate: concept label1 source documents7 linked claims
Jump to evidenceJump to sourcesJump to claims
Live refresh every 5sNext refresh in 5s

Evidence Snippets

the gain of mesenchymal markers (e.g., vimentin)
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1clinical correlationsupports2015Source 1DOIPubMed

In clinical microarray results, increased vimentin mRNA after chemotherapy correlated with poor prognosis in breast cancer patients.

Claim 2functional perturbationsupports2015Source 1DOIPubMed

Vimentin knockdown in MDA-MB 231 cells reduced cell proliferation, impaired wound healing, caused loss of directional migration, and increased large membrane extension.

Claim 3gain of functionsupports2015Source 1DOIPubMed

Vimentin overexpression in MCF7 cells increased cell stiffness, elevated cell motility and directional migration, reoriented microtubule polarity, and increased EMT phenotypes.

Claim 4mechanistic associationsupports2015Source 1DOIPubMed

The EMT-related transcription factor Slug was mediated by vimentin.

Claim 5mechanistic associationsupports2015Source 1DOIPubMed

The increased EMT phenotypes observed with vimentin overexpression in MCF7 cells were associated with increased β1-integrin and loss of E-cadherin.

Claim 6mechanistic effectsupports2015Source 1DOIPubMed

Vimentin depletion reorganized cytoskeletons and reduced focal adhesions, leading to impaired mechanical strength through reduced cell stiffness and contractile force.

Claim 7paper conclusionsupports2015Source 1DOIPubMed

Vimentin serves as a regulator that maintains intracellular mechanical homeostasis in EMT cancer cells by mediating cytoskeleton architecture and the balance of cell force generation.