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VIP-expressing interneurons

Candidate: concept label1 source documents6 linked claims
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Aliases

vasoactive intestinal peptide (VIP)-expressing interneurons, VIP interneurons

Extracted Explainers

What the tool is doing

The abstract presents VIP interneurons as regulators of hippocampal place-cell plasticity during exposure to novel environments.

Source 1DOI

What problem it solves

They are implicated in gating a temporal window for place-cell remapping and spatial learning.

Source 1DOI

Evidence Snippets

Here, we identify vasoactive intestinal peptide (VIP)-expressing interneurons as key regulators of this plasticity.
Evidence 1Source 1DOIprovenance

Supporting Sources

Linked Claims

Claim 1activity changesupports2025Source 1DOI

Novel environments trigger a transient increase in VIP interneuron activity.

Quoted textsource-backed
we show that novel environments trigger a transient increase in VIP interneuron activity
Claim 2behavioral effectsupports2025Source 1DOI

Both insufficient and excessive VIP interneuron activity impair reward-seeking behavior specifically in novel environments.

Quoted textsource-backed
Both insufficient and excessive VIP interneuron activity impair reward-seeking behavior specifically in novel environments
Claim 3causal perturbation effectsupports2025Source 1DOI

Bidirectional optogenetic manipulation of VIP interneuron activity modulates the speed of spatial map formation and alters BTSP signatures.

Quoted textsource-backed
Bidirectional optogenetic manipulation -suppressing or upregulating VIP interneuron activity- modulates the speed of spatial map formation and alters signatures of behavioral timescale plasticity (BTSP)
Claim 4functional effectsupports2025Source 1DOI

The transient increase in VIP interneuron activity facilitates rapid place-field formation and stable spatial map construction.

Quoted textsource-backed
which facilitates rapid place field formation and stable spatial map construction
Claim 5mechanistic modelsupports2025Source 1DOI

VIP interneurons gate a temporal window for place-cell plasticity that mediates the effect of environmental novelty on hippocampal remapping and spatial memory.

Quoted textsource-backed
VIP interneurons gate a temporal window for place cell plasticity, mediating the impact of environmental novelty on hippocampal remapping and spatial memory.
Claim 6mechanistic rolesupports2025Source 1DOI

VIP-expressing interneurons are key regulators of hippocampal place-cell plasticity during remapping in novel environments.

Quoted textsource-backed
Here, we identify vasoactive intestinal peptide (VIP)-expressing interneurons as key regulators of this plasticity.