Here, we identify vasoactive intestinal peptide (VIP)-expressing interneurons as key regulators of this plasticity.
First-pass extracted concept
VIP interneurons
Candidate: concept label1 source documents6 linked claims
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Aliases
vasoactive intestinal peptide (VIP)-expressing interneurons
Evidence Snippets
Supporting Sources
Linked Claims
Novel environments trigger a transient increase in VIP interneuron activity.
Quoted textsource-backed
Using all-optical methods in mice navigating virtual reality, we show that novel environments trigger a transient increase in VIP interneuron activity
Both insufficient and excessive VIP interneuron activity impair reward-seeking behavior specifically in novel environments, indicating that balanced VIP activity is required for spatial learning.
Quoted textsource-backed
Both insufficient and excessive VIP interneuron activity impair reward-seeking behavior specifically in novel environments, revealing that a precise balance of VIP activity is essential for spatial learning.
Increased VIP interneuron activity in novel environments facilitates rapid place field formation and stable spatial map construction.
Quoted textsource-backed
novel environments trigger a transient increase in VIP interneuron activity, which facilitates rapid place field formation and stable spatial map construction
VIP interneurons gate a temporal window for place-cell plasticity that mediates the effect of environmental novelty on hippocampal remapping and spatial memory.
Quoted textsource-backed
Our findings demonstrate that VIP interneurons gate a temporal window for place cell plasticity, mediating the impact of environmental novelty on hippocampal remapping and spatial memory.
VIP interneurons are key regulators of hippocampal place-cell plasticity during remapping in novel environments.
Quoted textsource-backed
Here, we identify vasoactive intestinal peptide (VIP)-expressing interneurons as key regulators of this plasticity.
Bidirectional optogenetic manipulation of VIP interneuron activity modulates the speed of spatial map formation and alters BTSP signatures.
Quoted textsource-backed
Bidirectional optogenetic manipulation —suppressing or upregulating VIP interneuron activity— modulates the speed of spatial map formation and alters signatures of behavioral timescale plasticity (BTSP)