Here we examined the organization and plasticity of microcircuits implicated in top-down control of 5-HT neurons in the dorsal raphe nucleus (DRN) by excitatory inputs from the ventromedial prefrontal cortex (vmPFC).
First-pass extracted concept
vmPFC to DRN excitatory input pathway
Candidate: concept label1 source documents5 linked claims
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Aliases
ventromedial prefrontal cortex inputs to the dorsal raphe nucleus, vmPFC-DRN pathway
Evidence Snippets
Supporting Sources
Linked Claims
Excitatory vmPFC projections in the DRN primarily localize to GABA-rich areas rather than serotonergic subregions.
Quoted textsource-backed
found that excitatory vmPFC projections primarily localized to GABA-rich areas of the DRN
Optogenetically increasing excitatory vmPFC input to the DRN during sensory exposure to aggressor cues enhances avoidance bias, whereas decreasing that input diminishes avoidance bias.
Quoted textsource-backed
optogenetically increasing or decreasing excitatory vmPFC input to the DRN during sensory exposure to an aggressor's cues enhances or diminishes avoidance bias, respectively
DRN GABAergic neurons act as a key cellular element filtering top-down vmPFC influences on affect-regulating 5-HT output.
Quoted textsource-backed
identify GABAergic neurons as a key cellular element filtering top-down vmPFC influences on affect-regulating 5-HT output
vmPFC axons drive synaptic activity and immediate early gene expression in genetically identified DRN GABA neurons through an AMPA receptor-dependent mechanism.
Quoted textsource-backed
vmPFC axons drive synaptic activity and immediate early gene expression in genetically identified DRN GABA neurons through an AMPA receptor-dependent mechanism
The authors did not detect vmPFC-driven synaptic activity in 5-HT neurons and observed only limited cFos induction in 5-HT neurons.
Quoted textsource-backed
we did not detect vmPFC-driven synaptic activity in 5-HT neurons and cFos induction in 5-HT neurons was limited