First-pass extracted concept

voltage sensors

Candidate: concept label2 source documents2 linked claims

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Extracted Explainers

What the tool is doing

Voltage sensors are identified as a major indicator class in the review. The abstract says the review focuses on their molecular design, properties, and current limitations.

Source 1DOI

Voltage sensors are described as part of the optogenetic sensor toolkit used to monitor neuronal activity.

Source 2DOI PubMed

Resources required

Their use depends on transgene expression in target neurons and optical methods for interrogation.

Source 2DOI PubMed

What problem it solves

They provide an optical way to monitor neuronal activity through voltage-related signals.

Source 1DOI

They support optical investigation of neuronal circuit function in living animals.

Source 2DOI PubMed

What it does not solve

The abstract does not state which performance limitations remain for voltage sensors.

Source 1DOI

Alternatives

Voltage sensors are presented alongside calcium, potassium, and neurotransmitter sensors as alternative indicator classes.

Source 1DOI

Evidence Snippets

We summarize recent advances of sensors for calcium, potassium, voltage, and select neurotransmitters, focusing on their molecular design, properties, and current limitations.

Evidence 1Source 1DOIprovenance

optogenetic sensors (i.e., genetically encoded calcium indicators and voltage sensors)

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1primary paper2019Applied SciencesDOI

1 evidence snippet 1 linked claim Claim 1

Source 2review2011Reviews in the NeurosciencesDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Linked Claims

Claim 1scope statementsupports2019Source 1DOI

Recent advances in genetically encoded indicators span calcium, potassium, voltage, and select neurotransmitter sensors.

Quoted textsource-backed

We summarize recent advances of sensors for calcium, potassium, voltage, and select neurotransmitters, focusing on their molecular design, properties, and current limitations.

Claim 2tool class coveragesupports2011Source 2DOI PubMed

The review covers recent advances in optogenetic sensors including genetically encoded calcium indicators and voltage sensors, and actuators including light-activated ion channels and ion pumps.

Quoted textsource-backed

we describe some of the most recent advances in the development and applications of optogenetic sensors (i.e., genetically encoded calcium indicators and voltage sensors) and actuators (i.e., light activated ion channels and ion pumps).