First-pass extracted concept

Wnt signaling

Candidate: concept label2 source documents6 linked claims

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Evidence Snippets

Studies using mice have yielded significant amounts of information regarding signaling pathways, such as Wnt

Evidence 1Source 1DOIprovenance

Wnt proteins are now recognized as one of the major families of developmentally important signaling molecules... we review our current understanding of Wnt function and signaling mechanisms, doing so in a comparative approach.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1review2008GastroenterologyDOI

1 evidence snippet 1 linked claim Claim 1

Source 2review1997Genes & DevelopmentDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1review scope summarysupports2008Source 1DOI

Mouse studies have provided substantial information about Wnt, bone morphogenic protein, PtdIns(3,4,5) kinase, and Notch signaling in intestinal development and homeostasis, including stem cell regulation and lineage specification and maturation.

Claim 2biological rolesupports1997Source 2DOI PubMed

Wnt proteins are described as functioning in embryonic induction, generation of cell polarity, and specification of cell fate.

Quoted textsource-backed

Among functions provided by Wnt proteins are such intriguing processes as embryonic induction, the generation of cell polarity, and the specification of cell fate.

Claim 3comparative pathway convergencesupports1997Source 2DOI PubMed

Insights from different animal systems are described as converging on a common Wnt pathway.

Quoted textsource-backed

These insights have come from different corners of the animal kingdom and have converged on a common pathway.

Claim 4disease linksupports1997Source 2DOI PubMed

Several components of Wnt signaling are implicated in the genesis of human cancer.

Quoted textsource-backed

several components of Wnt signaling are implicated in the genesis of human cancer

Claim 5mechanistic progresssupports1997Source 2DOI PubMed

Recent progress in the field included identification of cell-surface receptors for Wnt signaling and a novel mechanism for relaying the signal to the nucleus.

Quoted textsource-backed

over the past year, several major gaps have been filled. These include the identification of cell-surface receptors and a novel mechanism of relaying the signal to the cell nucleus.

Claim 6review summarysupports1997Source 2DOI PubMed

Wnt proteins are a major family of developmentally important signaling molecules.

Quoted textsource-backed

Wnt proteins are now recognized as one of the major families of developmentally important signaling molecules