This study employs network pharmacology and molecular docking techniques to uncover the mechanisms by which ZRGCDMD treats depression associated with insomnia.
First-pass extracted concept
Zao Ren Gan Cao Da Mai decoction
Candidate: concept label1 source documents5 linked claims
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Aliases
ZRGCDMD
Evidence Snippets
Supporting Sources
Linked Claims
Network pharmacology identified 244 active ingredients from ZRGCDMD.
Quoted textsource-backed
Using network pharmacology, 244 active ingredients were identified from ZRGCDMD
Eighty-eight targets associated with depression comorbid with insomnia were identified.
Quoted textsource-backed
Additionally, 88 targets associated with depression comorbid with insomnia were identified.
Zao Ren Gan Cao Da Mai decoction was studied with network pharmacology and molecular docking to explore its multitarget mechanism in insomnia comorbid with depression.
Quoted textsource-backed
This study employs network pharmacology and molecular docking techniques to uncover the mechanisms by which ZRGCDMD treats depression associated with insomnia.
GO and KEGG analyses indicated that ZRGCDMD may act through neuroactive ligand-receptor interactions, lipid metabolism, and the AGE-RAGE signaling pathway.
Quoted textsource-backed
Gene ontology and Kyoto encyclopedia of genes and genomes analyses revealed that ZRGCDMD operates through pathways including neuroactive ligand-receptor interactions, lipid metabolism, and the AGE-RAGE signaling pathway.
Protein-protein interaction network and molecular docking analyses indicated that IL1B, HIF1A, TP53, IL-6, AKT1, and TNF may be important targets for ZRGCDMD in depression comorbid with insomnia.
Quoted textsource-backed
protein-protein interaction network and molecular docking studies indicate that important targets, such as IL1B, HIF1A, TP53, IL-6, AKT1, and TNF, may be crucial for ZRGCDMD's effectiveness in treating depression comorbid with insomnia.