zebrafish cardiovascular disease model

The review presents zebrafish as an in vivo vertebrate model used to discover regulators of cardiac development and to study mechanisms of human cardiac disease. It is framed as a research model rather than a discrete engineered reagent.

Use of this model requires zebrafish husbandry plus genetic or variant-expression approaches to generate and study cardiovascular phenotypes.

It helps connect genetic perturbations or human disease-associated variants to cardiac developmental and disease phenotypes in a vertebrate system.

The abstract does not claim that zebrafish fully recapitulates all aspects of human cardiac disease or replaces other model systems.

The abstract does not explicitly name alternative model organisms or platforms.