In the mouse, the transcription factor, ZFHX3 (zinc finger homeobox-3), is necessary for the development of the SCN and influences circadian behaviour in the adult.
First-pass extracted concept
ZFHX3
Candidate: concept label2 source documents10 linked claims
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Aliases
Zfhx3, zinc finger homeobox-3
Evidence Snippets
In the mouse, the transcription factor, ZFHX3 (zinc finger homeobox-3), is necessary for the development of the SCN and influences circadian behaviour in the adult.
Supporting Sources
Linked Claims
ChIP-seq mapped genome-wide ZFHX3-binding sites in SCN chromatin, with occupancy predominantly around gene transcription start sites and co-localization with known histone modifications.
ZFHX3 preferentially partners with CLOCK and BMAL1 to regulate clock gene transcription in the SCN.
ZFHX3 mediates extensive genome-wide regulation of daily gene expression in the mouse suprachiasmatic nucleus.
Adult conditional loss of ZFHX3 dramatically alters the SCN transcriptome, including neuropeptide neurotransmitter system transcripts and attenuation of daily Bmal1 oscillation.
Altered circadian expression profiles of TTFL genes and clock-controlled genes in ZFHX3 conditional mutants are consistent with an advance in daily behavioural rhythms under 12 h light-12 h dark conditions.
Various TTFL genes and clock-controlled genes exhibit altered circadian expression profiles after ZFHX3 loss, consistent with an advance in daily behavioural rhythms under 12h light-12h dark conditions.
Quoted textsource-backed
various TTFL genes and CCGs exhibited altered circadian expression profiles, consistent with an advanced in daily behavioural rhythms under 12h light-12h dark conditions
Conditional loss of ZFHX3 in the adult has a dramatic effect on the SCN transcriptome, including altered transcripts for numerous neuropeptide neurotransmitter systems and attenuated daily oscillation of Bmal1.
Quoted textsource-backed
the conditional loss of ZFHX3 in the adult has a dramatic effect on the SCN transcriptome, including changes in the levels of transcripts encoding elements of numerous neuropeptide neurotransmitter systems while attenuating the daily oscillation of the clock TF Bmal1
ZFHX3 mediates extensive genome-wide regulation in the central clock that orchestrates daily timekeeping in mammals.
Quoted textsource-backed
Together, these findings reveal the extensive genome-wide regulation mediated by ZFHX3 in the central clock that orchestrates daily timekeeping in mammals.
ZFHX3 occupancy in SCN chromatin co-localizes with known histone modifications and preferentially partners with CLOCK and BMAL1 to regulate clock gene transcription.
Quoted textsource-backed
co-localizing with known histone modifications, and preferentially partnering with clock transcription factors (CLOCK, BMAL1) to regulate clock gene(s) transcription
ZFHX3 genome-wide occupancy in SCN chromatin occurs predominantly around gene transcription start sites.
Quoted textsource-backed
We show that the genome-wide occupancy of ZFHX3 occurs predominantly around gene transcription start sites (TSS)