First-pass extracted concept

Exocytic plasma membrane flows remodel endoplasmic reticulum–plasma membrane tethering for septin collar assembly

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Evidence Snippets

Exocytic plasma membrane flows remodel endoplasmic reticulum–plasma membrane tethering for septin collar assembly

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2024Science AdvancesDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1conceptual modelsupports2024Source 1DOI PubMed

The study proposes a mechanism that reconciles ER-septin competition on the plasma membrane.

Quoted textsource-backed

This study proposes machinery reconciling ER-septin competition on the PM, providing mechanistic insights into the spatial organization of PM-associated organelles and cytoskeletons.

Claim 2mechanistic claimsupports2024Source 1DOI PubMed

Plasma membrane flows driven by polarized exocytosis extrude plasma membrane proteins, including ER-PM tethering proteins, from bud sites.

Quoted textsource-backed

Our results suggest that PM flows by polarized exocytosis extrude PM proteins, including ER-PM tethering proteins, from the bud sites.

Claim 3mechanistic claimsupports2024Source 1DOI PubMed

Upon septin collar assembly, ER-PM tethering proteins are excluded from yeast bud sites and the PM-associated ER is locally detached from the plasma membrane.

Quoted textsource-backed

Here, we show that, upon septin collar assembly, ER-PM tethering proteins are excluded from the yeast bud sites, and the PM-associated ER is locally detached from the PM.

Claim 4perturbation effectsupports2024Source 1DOI PubMed

When ER-PM tethering reorganization is inhibited by exocytosis repression, septin localization is restricted to plasma membrane sites poor in ER-PM tethering proteins.

Quoted textsource-backed

When the reorganization of the ER-PM tethering was inhibited by exocytosis repression, septin localization was restricted to the PM sites poor in ER-PM tethering proteins.