The effects of 6-dimethylaminopurine (6-DMAP), known to reversibly block cell division in many systems through inhibition of protein kinase activity, are described here for Gonyaulax.
First-pass extracted concept
6-dimethylaminopurine
Candidate: toolkit item1 source documents6 linked claims
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Aliases
6-DMAP
Evidence Snippets
Supporting Sources
Linked Claims
In Gonyaulax polyedra, continuous exposure to 6-DMAP lengthens the circadian period in a concentration-dependent fashion.
Quoted textsource-backed
in cells continuously exposed, the period is lengthened in a concentration-dependent fashion
Short treatments with 5 mM 6-DMAP apparently stop the circadian oscillator reversibly in Gonyaulax polyedra.
Quoted textsource-backed
Shorter treatments at a higher concentration of 6-DMAP (5 mM) apparently stop the circadian oscillator, but reversibly so
6-DMAP is effective in inhibiting many Gonyaulax protein kinases in vitro.
Quoted textsource-backed
6-DMAP completely blocks light-induced phase advances and is effective in inhibiting many Gonyaulax protein kinases in vitro.
6-DMAP completely blocks light-induced phase advances in Gonyaulax polyedra.
Quoted textsource-backed
6-DMAP completely blocks light-induced phase advances
Pulses of 6-DMAP cause phase delays at all times of the circadian cycle in Gonyaulax polyedra.
Quoted textsource-backed
Pulses of the inhibitor are effective in causing phase delays at all times of the circadian cycle.
After removal of 6-DMAP, the circadian rhythm resumes with a phase delay approximately equal to the duration of treatment.
Quoted textsource-backed
the rhythm resumes after drug removal with a phase delay approximately equal to the duration of the treatment