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Activation-induced deaminase

Candidate: toolkit item1 source documents5 linked claims
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Aliases

AID

Evidence Snippets

Activation-induced deaminase (AID) initiates somatic hypermutation, gene conversion and class switch recombination
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1interaction mediationsupports2010Source 1DOIPubMed

The AID/CIB1 interaction is unlikely to be mediated by nucleic acid because it resisted DNase and RNase treatment.

Quoted textsource-backed
The AID/CIB1 resisted DNase and RNase treatment, and it is therefore unlikely to be mediated by nucleic acid.
Claim 2molecular functionsupports2010Source 1DOIPubMed

AID initiates somatic hypermutation, gene conversion, and class switch recombination by deaminating variable and switch region DNA cytidines to uridines.

Quoted textsource-backed
Activation-induced deaminase (AID) initiates somatic hypermutation, gene conversion and class switch recombination by deaminating variable and switch region DNA cytidines to uridines.
Claim 3protein interactionsupports2010Source 1DOIPubMed

CIB1 was identified as an AID-interacting protein in a yeast-based screen, and the interaction was confirmed by immunoprecipitation.

Quoted textsource-backed
The calcium and integrin binding protein CIB1 was identified by sequencing and the interaction was confirmed by immunoprecipitation experiments.
Claim 4subcellular localizationsupports2010Source 1DOIPubMed

AID is predominantly cytoplasmic and must enter the nucleus to initiate antibody gene diversification reactions.

Quoted textsource-backed
AID is predominantly cytoplasmic and must enter the nuclear compartment to initiate these distinct antibody gene diversification reactions.
Claim 5subcellular localization effectsupports2010Source 1DOIPubMed

AID-EGFP subcellular localization is normal in the DT40 system under CIB1 over-expression conditions.

Quoted textsource-backed
The DT40 system was also used to show that CIB1 over-expression has no effect on gene conversion and that AID-EGFP subcellular localization is normal.