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First-pass extracted concept

AnsACR

Candidate: toolkit item1 source documents4 linked claims
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Aliases

Ancyromonas sigmoides ACR

Extracted Explainers

What the tool is doing

AnsACR is a naturally blue-shifted ancyromonad channelrhodopsin used as an inhibitory optogenetic actuator. The abstract states that it enabled silencing in mouse cortical neurons and photoinhibition of pharyngeal muscle contraction in live worms.

Source 1DOIPubMed

Resources required

Use requires expression of AnsACR in target cells and light delivery. The worm application specifically used expression in cholinergic neurons.

Source 1DOIPubMed

What problem it solves

It helps provide spectral separation for multiplex optogenetics while preserving channel function through use of a natural homolog rather than an engineered spectral variant.

Source 1DOIPubMed

Alternatives

The abstract contrasts these natural blue-shifted ChRs with previously known tools having similar spectral maxima and notes that engineering spectral separation can disrupt channel function.

Source 1DOIPubMed

Evidence Snippets

Ancyromonas sigmoides ACR (AnsACR) expression in cholinergic neurons enabled photoinhibition of pharyngeal muscle contraction in live worms.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1applicationsupports2025Source 1DOIPubMed

Ancyromonad channelrhodopsins can be activated by near-infrared two-photon illumination.

Quoted textsource-backed
Ancyromonad ChRs could be activated by near-infrared two-photon illumination
Claim 2applicationsupports2025Source 1DOIPubMed

AnsACR expression in cholinergic neurons enabled photoinhibition of pharyngeal muscle contraction in live worms.

Quoted textsource-backed
Ancyromonas sigmoides ACR (AnsACR) expression in cholinergic neurons enabled photoinhibition of pharyngeal muscle contraction in live worms.
Claim 3applicationsupports2025Source 1DOIPubMed

Both ancyromonad ACRs allowed optogenetic silencing of mouse cortical neurons in brain slices.

Quoted textsource-backed
Both ancyromonad ACRs allowed optogenetic silencing of mouse cortical neurons in brain slices.
Claim 4mechanismsupports2025Source 1DOIPubMed

The identified ancyromonad channelrhodopsins contain residue motifs characteristic of anion channelrhodopsins, but only two conduct chloride.

Quoted textsource-backed
They form a separate branch on the phylogenetic tree and contain residue motifs characteristic of anion ChRs (ACRs). However, only two conduct chloride