First-pass extracted concept

ASMase(S508A) mutant

Candidate: toolkit item1 source documents4 linked claims

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Aliases

ASMase(S508A), ASMase(S508A) mutant

Evidence Snippets

cells overexpressing the ASMase(S508A) mutant, which could not be phosphorylated

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2007The FASEB JournalDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1bax activation differencesupports2007Source 1DOI PubMed

ASMase(S508A) cells have less active Bax than ASMase(WT) cells.

Quoted textsource-backed

ASMase(S508A) cells had 50% less active Bax than ASMase(WT) cells.

Claim 2cell death differencesupports2007Source 1DOI PubMed

Cells expressing ASMase(S508A) are more resistant to UVC-induced cell death than cells expressing ASMase(WT).

Quoted textsource-backed

These molecular differences culminated in resistance of ASMase(S508) cells to UVC-induced cell death (25%) as compared to ASMase(WT) cells (46%).

Claim 3mutation effectsupports2007Source 1DOI PubMed

The nonphosphorylatable ASMase(S508A) mutant abolishes UV-induced changes in ASMase activity and ceramide levels.

Quoted textsource-backed

cells overexpressing the ASMase(S508A) mutant, which could not be phosphorylated, had no change in either ASMase activity or ceramide levels post-UV radiation.

Claim 4protective effectsupports2007Source 1DOI PubMed

Overexpression of ASMase(S508A) protects cells from UV-induced mitochondrial fragmentation.

Quoted textsource-backed

cells overexpressing ASMase(S508A) were protected (>50%) from UV light-induced mitochondrial fragmentation.