First-pass extracted concept

Blue light Inhibitor of Cryptochromes 2

Candidate: toolkit item1 source documents6 linked claims
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Aliases

BIC2

Evidence Snippets

Blue light Inhibitors of Cryptochromes 1 and 2 (BIC1 and BIC2)
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1feedback circuitsupports2017Source 1DOIPubMed

CRY and BIC form a negative-feedback circuitry that regulates each other's activity.

Quoted textsource-backed
These results demonstrate a CRY-BIC negative-feedback circuitry that regulates the activity of each other.
Claim 2pathway mechanismsupports2017Source 1DOIPubMed

Cryptochromes activate BIC gene transcription by suppressing COP1 activity, resulting in activation of HY5 associated with chromatins of the BIC promoters.

Quoted textsource-backed
by suppressing the activity of CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1), resulting in activation of the transcription activator ELONGATED HYPOCOTYL 5 (HY5) that is associated with chromatins of the BIC promoters
Claim 3physiological functionsupports2017Source 1DOIPubMed

Photoreceptor co-action in activating BIC transcription may sustain blue light sensitivity of plants under broad spectra of solar radiation in nature.

Quoted textsource-backed
suggesting a novel photoreceptor co-action mechanism to sustain blue light sensitivity of plants under the broad spectra of solar radiation in nature.
Claim 4regulatory mechanismsupports2017Source 1DOIPubMed

BIC1 and BIC2 inhibit Arabidopsis cryptochrome function by blocking blue light-dependent cryptochrome dimerization.

Quoted textsource-backed
two negative regulators of Arabidopsis cryptochromes, Blue light Inhibitors of Cryptochromes 1 and 2 (BIC1 and BIC2), inhibit cryptochrome function by blocking blue light-dependent cryptochrome dimerization
Claim 5transcriptional regulationsupports2017Source 1DOIPubMed

Cryptochromes mediate light activation of transcription of the BIC genes.

Quoted textsource-backed
Here we show that cryptochromes mediate light activation of transcription of the BIC genes
Claim 6transcriptional regulationsupports2017Source 1DOIPubMed

Phytochromes also mediate light activation of BIC transcription.

Quoted textsource-backed
Surprisingly, phytochromes also mediate light activation of BIC transcription