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blue wavelength light

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Aliases

470 nm light, blue light

Evidence Snippets

Exposure to blue light (470 nm) resulted in upregulation of several immediate early genes
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1cell type specificitysupports2019Source 1DOIPubMed

Blue light-induced immediate early gene induction persisted in AraC-treated cortical cultures, indicating induction in postmitotic neurons.

Quoted textsource-backed
Induction of IEGs by blue light was maintained in cortical cultures treated with AraC to block glial proliferation, indicating that induction occurred selectively in postmitotic neurons.
Claim 2gene expression effectsupports2019Source 1DOIPubMed

In cultured primary rat cortical cells, blue light exposure upregulates immediate early genes including Fos and Fosb.

Quoted textsource-backed
Exposure to blue light (470 nm) resulted in upregulation of several immediate early genes (IEGs) traditionally used as markers of neuronal activity, including <i>Fos</i> and <i>Fosb</i> ... IEG expression was increased following 4 h of 5% duty cycle light exposure
Claim 3gene expression no effectsupports2019Source 1DOIPubMed

Blue light exposure did not alter expression of the circadian clock genes Bmal1, Cry1, Cry2, Clock, or Per2 in cultured primary rat cortical cells.

Quoted textsource-backed
but did not alter the expression of circadian clock genes <i>Bmal1</i>, <i>Cry1</i>, <i>Cry2</i>, <i>Clock</i>, or <i>Per2</i>
Claim 4mechanistic interpretationsupports2019Source 1DOIPubMed

The abstract concludes that in vitro light-induced gene expression alterations stem from a phototoxic interaction between commonly used media and neurons.

Quoted textsource-backed
Together, these findings suggest that light-induced gene expression alterations observed <i>in vitro</i> stem from a phototoxic interaction between commonly used media and neurons
Claim 5mitigation effectsupports2019Source 1DOIPubMed

Photoinert media with a photostable neuronal supplement prevented blue light-induced gene expression changes in culture.

Quoted textsource-backed
changes in gene expression induced by blue wavelength light were prevented when cultures were maintained in a photoinert media supplemented with a photostable neuronal supplement
Claim 6parameter dependencesupports2019Source 1DOIPubMed

Immediate early gene induction by blue light was not dependent on light pulse width.

Quoted textsource-backed
IEG induction was not dependent on light pulse width
Claim 7toxicity effectsupports2019Source 1DOIPubMed

Elevated blue light exposure reduced cell viability in vitro, consistent with overt phototoxicity.

Quoted textsource-backed
Elevated levels of blue light exposure induced a loss of cell viability <i>in vitro</i>, suggestive of overt phototoxicity.