this photoactivated adenylyl cyclase (bPAC)
First-pass extracted concept
bPAC
Candidate: toolkit item1 source documents5 linked claims
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Aliases
light activatable adenylate cyclase, optogenetic analogue of adenylate cyclase, photoactivated adenylyl cyclase, photo-activated adenylyl cyclase bPAC, small bacterial photoactivated adenylyl cyclase
Evidence Snippets
Supporting Sources
Linked Claims
bPAC is a light-activated adenylyl cyclase with low activity in darkness and strongly increased activity in light.
Quoted textsource-backed
this photoactivated adenylyl cyclase (bPAC) showed cyclase activity that is low in darkness but increased 300-fold in the light
bPAC is well expressed in pyramidal neurons and, together with cyclic nucleotide gated channels, enables efficient light-induced depolarization.
Quoted textsource-backed
bPAC is well expressed in pyramidal neurons and, in combination with cyclic nucleotide gated channels, causes efficient light-induced depolarization
In the Drosophila central nervous system, bPAC mediates light-dependent cAMP increase and behavioral changes in freely moving animals.
Quoted textsource-backed
In the Drosophila central nervous system, bPAC mediates light-dependent cAMP increase and behavioral changes in freely moving animals
The light-activated enzymatic activity of bPAC decays thermally within 20 seconds in parallel with the red-shifted BLUF photointermediate.
Quoted textsource-backed
This enzymatic activity decays thermally within 20 s in parallel with the red-shifted BLUF photointermediate
bPAC is presented as an optogenetic tool for light modulation of cAMP in neuronal cells and tissues and for studying cAMP-dependent processes in live animals.
Quoted textsource-backed
bPAC seems a perfect optogenetic tool for light modulation of cAMP in neuronal cells and tissues and for studying cAMP-dependent processes in live animals