Photocaging is one specific class of modifications for silencing oligonucleotides that block their bioactivity until exposure to near-ultraviolet light. These caged RNAi effectors enable both spatial and temporal targeting of a dosed release of gene silencing agents by directed light exposure that photocleaves the cage moieties.
First-pass extracted concept
caged siRNAs
Candidate: toolkit item1 source documents4 linked claims
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Aliases
caged RNAi effectors, photocaged siRNA
Evidence Snippets
Supporting Sources
Linked Claims
Light-controllable caged siRNA strategies are described as having potential for probing developing biological systems and for targeted gene-silencing therapeutics.
Quoted textsource-backed
This light-controllable strategy has potential applications for precisely probing developing biological systems and eventually enabling targeted gene-silencing therapeutics.
Caged RNAi effectors enable spatial and temporal control of gene silencing through directed light exposure.
Quoted textsource-backed
These caged RNAi effectors enable both spatial and temporal targeting of a dosed release of gene silencing agents by directed light exposure that photocleaves the cage moieties.
The review compares photochemical properties of cage compounds and their use when attached randomly or site-specifically to silencing oligonucleotides.
Quoted textsource-backed
Herein we compare the photochemical properties of cage compounds and strategies for their use, attached either randomly or site-specifically
Photocaging modifications can keep silencing oligonucleotides inactive until near-ultraviolet light exposure removes the cage and restores activity.
Quoted textsource-backed
Photocaging is one specific class of modifications for silencing oligonucleotides that block their bioactivity until exposure to near-ultraviolet light.