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Channelrhodopsin-2–XXL

Candidate: toolkit item1 source documents5 linked claims
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Aliases

ChR2-XXL, D156C mutant

Evidence Snippets

Here, we describe the D156C mutant, termed ChR2-XXL (extra high expression and long open state)
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1application resultsupports2014Source 1DOIPubMed

ChR2-XXL benefits were validated in intact flies by eliciting simple and complex behaviors.

Quoted textsource-backed
We validated the benefits of the variant in intact flies by eliciting simple and complex behaviors.
Claim 2application resultsupports2014Source 1DOIPubMed

ChR2-XXL supports efficient and prolonged photostimulation of monosynaptic transmission at the neuromuscular junction and reliable activation of a gustatory reflex pathway.

Quoted textsource-backed
We demonstrate efficient and prolonged photostimulation of monosynaptic transmission at the neuromuscular junction and reliable activation of a gustatory reflex pathway.
Claim 3behavioral applicationsupports2014Source 1DOIPubMed

ChR2-XXL-triggered photostimulation induced innate male courtship in male and female flies and enabled writing of olfactory memories through light-induced associative training.

Quoted textsource-backed
Innate male courtship was triggered in male and female flies, and olfactory memories were written through light-induced associative training.
Claim 4functional capabilitysupports2014Source 1DOIPubMed

ChR2-XXL enables efficient evocation of neuronal activity with ambient light and without retinal supplementation.

Quoted textsource-backed
As a result, neuronal activity could be efficiently evoked with ambient light and even without retinal supplementation.
Claim 5molecular propertysupports2014Source 1DOIPubMed

ChR2-XXL displays increased expression, improved subcellular localization, elevated retinal affinity, an extended open-state lifetime, and photocurrent amplitudes greater than previously published ChR variants.

Quoted textsource-backed
Here, we describe the D156C mutant, termed ChR2-XXL (extra high expression and long open state), which displays increased expression, improved subcellular localization, elevated retinal affinity, an extended open-state lifetime, and photocurrent amplitudes greatly exceeding those of all heretofore published ChR variants.