One of the down-regulated genes encodes a protein called Cib2 (calcium- and integrin-binding protein 2)
First-pass extracted concept
Cib2
Candidate: toolkit item1 source documents5 linked claims
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Aliases
calcium- and integrin-binding protein 2
Evidence Snippets
Supporting Sources
Linked Claims
Cib2 is a calcium-binding protein that interacts with integrin alpha7Bbeta1D.
Quoted textsource-backed
Finally, we demonstrate that Cib2 is a calcium-binding protein that interacts with integrin alpha7Bbeta1D.
In skeletal muscle, Cib2 colocalizes with the integrin alpha7B subunit at the sarcolemma and at the neuromuscular and myotendinous junctions.
Quoted textsource-backed
In skeletal muscle, Cib2 colocalizes with the integrin alpha7B subunit at the sarcolemma and at the neuromuscular and myotendinous junctions.
Cib2 is down-regulated in laminin alpha2 chain-deficient mouse limb muscle.
Quoted textsource-backed
we performed gene expression profiling of laminin alpha2 chain-deficient mouse limb muscle. One of the down-regulated genes encodes a protein called Cib2
Cib2 mRNA is mainly expressed in the developing central nervous system and in developing and adult skeletal muscle.
Quoted textsource-backed
Cib2 mRNA is mainly expressed in the developing central nervous system and in developing and adult skeletal muscle.
The data suggest that Cib2 may act as a cytoplasmic effector of integrin alpha7Bbeta1D signaling in skeletal muscle.
Quoted textsource-backed
Thus, our data suggest a role for Cib2 as a cytoplasmic effector of integrin alpha7Bbeta1D signaling in skeletal muscle.