First-pass extracted concept

CRISPR/Cas-based repressors

Candidate: toolkit item1 source documents3 linked claims

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Extracted Explainers

What the tool is doing

The review lists CRISPR/Cas-based repressors among the main systems used for targeted suppression of gene expression in plants and animals.

Source 1DOI PubMed

What problem it solves

They are presented as one of the available methods for suppressing expression of a gene of interest.

Source 1DOI PubMed

Alternatives

The abstract compares them with RNAi, chimeric transcription factors, chimeric zinc finger proteins, TALE-based repressors, and optogenetic tools.

Source 1DOI PubMed

Evidence Snippets

including RNA interference (RNAi), chimeric transcription factors, chimeric zinc finger proteins, transcription activator-like effectors (TALEs)-based repressors, optogenetic tools, and CRISPR/Cas-based repressors

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2024International Journal of Molecular SciencesDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1application scopesupports2024Source 1DOI PubMed

The reviewed targeted gene-silencing systems are applied in eukaryotes including plants and animals.

Claim 2comparative review statementsupports2024Source 1DOI PubMed

The review considers advantages and disadvantages of each targeted gene-silencing approach, compares their effectiveness, and discusses usage peculiarities in plant and animal organisms.

Claim 3review scopesupports2024Source 1DOI PubMed

The review describes RNA interference, chimeric transcription factors, chimeric zinc finger proteins, TALE-based repressors, optogenetic tools, and CRISPR/Cas-based repressors as main systems for targeted suppression of gene expression.