First-pass extracted concept

CRY2 INTERACTING SPLICING FACTOR 1

Candidate: toolkit item1 source documents4 linked claims

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Aliases

CIS1

Evidence Snippets

CRY2 INTERACTING SPLICING FACTOR 1 (CIS1) interacts with CRY2 in a blue light-dependent manner.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2022Nature CommunicationsDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1molecular interactionsupports2022Source 1DOI PubMed

CIS1 interacts with CRY2 in a blue light-dependent manner and promotes CRY2-mediated thermosensory flowering.

Quoted textsource-backed

CRY2 INTERACTING SPLICING FACTOR 1 (CIS1) interacts with CRY2 in a blue light-dependent manner and promotes CRY2-mediated thermosensory flowering.

Claim 2pathway modelsupports2022Source 1DOI PubMed

Blue light regulates thermosensory flowering via a CRY2-CIS1-FLM signaling pathway linking flowering responses to light and ambient temperature.

Quoted textsource-backed

Thus, blue light regulates thermosensory flowering via a CRY2-CIS1-FLM signaling pathway that links flowering responses to both light and ambient temperature.

Claim 3regulation of splicingsupports2022Source 1DOI PubMed

Blue light, CRYs, and CISs affect transcriptome-wide alternative splicing profiles, including FLM.

Quoted textsource-backed

Blue light, CRYs, and CISs affect transcriptome-wide AS profiles, including those of FLOWERING LOCUS M (FLM), which is critical for temperature modulation of flowering.

Claim 4rna binding and regulationsupports2022Source 1DOI PubMed

CIS1 binds FLM pre-mRNA to regulate its alternative splicing, and CRY2 regulates the RNA-binding activity of CIS1.

Quoted textsource-backed

Moreover, CIS1 binds to the FLM pre-mRNA to regulate its AS, while CRY2 regulates the RNA-binding activity of CIS1.