First-pass extracted concept

endocannabinoids

Candidate: toolkit item1 source documents3 linked claims

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Aliases

endogenous cannabinoids

Evidence Snippets

identification of endogenous compounds with cannabimimetic activity (endocannabinoids)

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2003Physiological ReviewsDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1review scope statementneutral2003Source 1DOI PubMed

The review covers synthetic pathways of endocannabinoids and putative mechanisms of their release, uptake, and degradation.

Quoted textsource-backed

First, the synthetic pathways of endocannabinoids are discussed, along with the putative mechanisms of their release, uptake, and degradation.

Claim 2review summarysupports2003Source 1DOI PubMed

The review discusses possible functions of endocannabinoids as retrograde synaptic signal molecules in relation to synaptic plasticity and network activity patterns.

Quoted textsource-backed

Finally, the possible functions of endocannabinoids as retrograde synaptic signal molecules are discussed in relation to synaptic plasticity and network activity patterns.

Claim 3review summarysupports2003Source 1DOI PubMed

The review states that endocannabinoids are involved in retrograde signaling at GABAergic and glutamatergic synapses.

Quoted textsource-backed

Subsequent discoveries shed light on the functional consequences of this localization by demonstrating the involvement of endocannabinoids in retrograde signaling at GABAergic and glutamatergic synapses.