These findings show that functional Opn3 and Opn4 in PAs represent an endogenous "optogenetic system" that mediates photorelaxation in the pulmonary vasculature.
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endogenous optogenetic system
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Blue light induces significant vasorelaxation in pulmonary arteries from rats with chronic pulmonary hypertension and lowers pulmonary arterial pressure in isolated intact perfused rat lungs subjected to acute hypoxia.
Quoted textsource-backed
Most importantly, blue light induced significant vasorelaxation of PAs from rats with chronic pulmonary hypertension and effectively lowered pulmonary arterial pressure in isolated intact perfused rat lungs subjected to acute hypoxia.
Light induces intensity-dependent relaxation of phenylephrine-preconstricted pulmonary arteries with a maximal response between 400 and 460 nm.
Quoted textsource-backed
Light elicited an intensity-dependent relaxation of PAs preconstricted with phenylephrine (PE), with a maximum response between 400 and 460 nm (blue light).
Wavelength-specific pulmonary artery photorelaxation is attenuated in Opn4 knockout tissue and further reduced after Opn3 knockdown.
Quoted textsource-backed
Wavelength-specific photorelaxation was attenuated in PAs from Opn4<sup>-/-</sup> mice and further reduced following shRNA-mediated knockdown of Opn3.
The pulmonary photorelaxation response is modulated by soluble guanylyl cyclase but not by protein kinase G or nitric oxide.
Quoted textsource-backed
The photorelaxation response was modulated by soluble guanylyl cyclase but not by protein kinase G or nitric oxide.
GRK2 inhibition amplifies pulmonary photorelaxation and prevents physiological desensitization to repeated light exposure.
Quoted textsource-backed
Inhibition of GRK2 amplified the response and prevented physiological desensitization to repeated light exposure.
Functional Opsin 3 and Opsin 4 in pulmonary arteries constitute an endogenous optogenetic system that mediates photorelaxation in the pulmonary vasculature.
Quoted textsource-backed
These findings show that functional Opn3 and Opn4 in PAs represent an endogenous "optogenetic system" that mediates photorelaxation in the pulmonary vasculature.