KSHV interacts and activates EphrinA2 (EphA2)
First-pass extracted concept
EphA2
Candidate: toolkit item1 source documents4 linked claims
Live refresh every 5sNext refresh in 5s
Aliases
EphrinA2
Evidence Snippets
Supporting Sources
Linked Claims
CIB1 plays a role in KSHV entry and macropinocytosis and is suggested to coordinate and sustain EphA2-mediated signaling involved in viral entry.
Quoted textsource-backed
Collectively, these studies revealed for the first time that CIB1 plays a role in virus entry and macropinocytosis, and suggested that KSHV utilizes CIB1 as one of the key molecule(s) to coordinate and sustain the EphA2 mediated signaling involved in its entry
Mass spectrometry revealed simultaneous association of CIB1 and EphA2 with myosin IIA and alpha-actinin 4, and CIB1 knockdown reduced EphA2 association with these cytoskeletal regulators.
Quoted textsource-backed
Mass spectrometry revealed the simultaneous association of CIB1 and EphA2 with the actin cytoskeleton modulating myosin IIA and alpha-actinin 4 molecules, and CIB1 knockdown reduced EphA2's association with myosin IIA and alpha-actinin 4.
Infection increased the association of CIB1 with lipid rafts, and CIB1 was associated with EphA2 and KSHV entry-associated signaling molecules including Src, PI3-K, and c-Cbl.
Quoted textsource-backed
Infection increased the association of CIB1 with LRs, and CIB1 was associated with EphA2 and KSHV entry associated signal molecules such as Src, PI3-K, and c-Cbl.
CIB1 knockdown significantly reduced infection-induced EphA2, Src, and Erk1/2 activation.
Quoted textsource-backed
CIB1 knockdown significantly reduced the infection induced EphA2, Src and Erk1/2 activation.