First-pass extracted concept

ER–TGN contact sites

Candidate: toolkit item1 source documents3 linked claims

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Aliases

ERTGoCS

Evidence Snippets

the contact sites between the ER and the TGN (ERTGoCS)

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2019The Journal of Cell BiologyDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1functional requirementsupports2019Source 1DOI PubMed

ER–TGN contact sites are necessary but not sufficient for Sac1 phosphatase activity on TGN PI4P because FAPP1 is also required.

Quoted textsource-backed

The ERTGoCS, though necessary, are not sufficient for the phosphatase activity of Sac1 on TGN PI4P, since this needs the phosphatidyl-four-phosphate-adaptor-protein-1 (FAPP1).

Claim 2functional requirementsupports2019Source 1DOI PubMed

ER–TGN contact sites provide a spatial setting suitable for Sac1 to dephosphorylate PI4P at the TGN.

Quoted textsource-backed

the contact sites between the ER and the TGN (ERTGoCS) provide a spatial setting suitable for Sac1 to dephosphorylate PI4P at the TGN

Claim 3localization interactionsupports2019Source 1DOI PubMed

FAPP1 localizes at ER–TGN contact sites and interacts with Sac1.

Quoted textsource-backed

FAPP1 localizes at ERTGoCS, interacts with Sac1